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Series GSE51498 Query DataSets for GSE51498
Status Public on Sep 19, 2015
Title Regulation of HSF1-mediated transcriptional programs by PGC-1alpha
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary We examined global gene expression patterns in response to PGC-1 expression in cells derived from liver or muscle.
As our study revealed regulation of HSF1 by PGC-1alpha, in some experiments we knocked-down HSF1 using siRNAs in addition to inducing PGC-1alpha expression.
 
Overall design Cells were grown in 24-well plates and adenoviruses encoding either GFP ("Ad-GFP"), PGC-1alpha ("Ad-PGC-1alpha") or PGC-1beta ("Ad-PGC-1beta") were directly added to the culture medium. For experiments involving siRNA transfections, cells were transfected with the indicated siRNAs 48hr prior to infection with adenoviruses encoding either GFP ("Ad-GFP") or PGC-1alpha ("Ad-PGC-1alpha").
 
Contributor(s) Minsky N, Roeder RG
Citation(s) 26438876
Submission date Oct 21, 2013
Last update date Mar 04, 2019
Contact name Neri Minsky
E-mail(s) nminsky@rockefeller.edu
Organization name Rockefeller University
Lab Laboratory of Biochemistry and Molecular Biology
Street address 1230 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
 
Platforms (2)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (19)
GSM1246575 Human primary hepatocytes donor 1 infected with Ad-GFP
GSM1246576 Human primary hepatocytes donor 2 infected with Ad-GFP
GSM1246577 Human primary hepatocytes donor 3 infected with Ad-GFP
Relations
BioProject PRJNA223320

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51498_RAW.tar 86.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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