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Status |
Public on Sep 18, 2014 |
Title |
Next generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-diagnosed advanced/metastatic PCa. As proof of concept, we undertook in vivo gene expression profiling by next generation RNA sequencing (RNA-Seq).
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Overall design |
Tumour biposies from 6 patients were taken before and after treatment with combined ADT and docetaxcel for 6 weeks
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Contributor(s) |
Sudbery I, Rajan P, Stockley J, Fleming J, Davis M, Abdul Razak AR, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY |
Citation(s) |
25519703 |
Submission date |
Sep 19, 2013 |
Last update date |
May 15, 2019 |
Contact name |
Ian Sudbery |
E-mail(s) |
i.sudbery@sheffield.ac.uk
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Organization name |
University of Sheffield
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Department |
Molecular Biology and Biotechnology
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Lab |
Sudbery Lab for Computational Genomics
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Street address |
Firth Court, Western Bank
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City |
Sheffield |
ZIP/Postal code |
S11 8HG |
Country |
United Kingdom |
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Platforms (1) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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Samples (12)
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Relations |
BioProject |
PRJNA219507 |
SRA |
SRP030027 |