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Series GSE51005 Query DataSets for GSE51005
Status Public on Sep 18, 2014
Title Next generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-diagnosed advanced/metastatic PCa. As proof of concept, we undertook in vivo gene expression profiling by next generation RNA sequencing (RNA-Seq).
Overall design Tumour biposies from 6 patients were taken before and after treatment with combined ADT and docetaxcel for 6 weeks
Contributor(s) Sudbery I, Rajan P, Stockley J, Fleming J, Davis M, Abdul Razak AR, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY
Citation(s) 25519703
Submission date Sep 19, 2013
Last update date May 15, 2019
Contact name Ian Sudbery
Organization name University of Sheffield
Department Molecular Biology and Biotechnology
Lab Sudbery Lab for Computational Genomics
Street address Firth Court, Western Bank
City Sheffield
ZIP/Postal code S11 8HG
Country United Kingdom
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (12)
GSM1234521 tax-Pre-R1
GSM1234522 tax-Pre-R2
GSM1234523 tax-Pre-R3
BioProject PRJNA219507
SRA SRP030027

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51005_refcoding_tax_pre_vs_postDesign_edgeR_results.tsv.gz 707.2 Kb (ftp)(http) TSV
GSE51005_refcoding_tax_read_counts.tsv.gz 394.4 Kb (ftp)(http) TSV
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Raw data are available in SRA
Processed data are available on Series record

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