|
| Status |
Public on Sep 18, 2014 |
| Title |
Next generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-diagnosed advanced/metastatic PCa. As proof of concept, we undertook in vivo gene expression profiling by next generation RNA sequencing (RNA-Seq).
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| |
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| Overall design |
Tumour biposies from 6 patients were taken before and after treatment with combined ADT and docetaxcel for 6 weeks
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| |
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| Contributor(s) |
Sudbery I, Rajan P, Stockley J, Fleming J, Davis M, Abdul Razak AR, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY |
| Citation(s) |
25519703 |
| |
| Submission date |
Sep 19, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Ian Sudbery |
| E-mail(s) |
i.sudbery@sheffield.ac.uk
|
| Organization name |
University of Sheffield
|
| Department |
Molecular Biology and Biotechnology
|
| Lab |
Sudbery Lab for Computational Genomics
|
| Street address |
Firth Court, Western Bank
|
| City |
Sheffield |
| ZIP/Postal code |
S11 8HG |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA219507 |
| SRA |
SRP030027 |
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