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Series GSE50855 Query DataSets for GSE50855
Status Public on May 22, 2014
Title Gene Expression Analysis of Host Immune Responses in CD11b positive cells isolated from lungs of the UV inactivated SARS-CoV-immunized mice following Lethal SARS-CoV Infection
Organism Mus musculus
Experiment type Expression profiling by array
Summary To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in macrophages from the lungs of mouse.
Overall design Female BALB/c mice were used at 21 weeks of age. Mice were subcutaneously immunized with UV inactivated SARS-CoV (UV-V) or UV-V and Toll like receptor (TLR) ligands at 6 and 1 weeks prior to mouse-adapted SARS-CoV (n=6 per group). Mice were intranasally challenged with 1E+6 TCID50 in 30μL. MEM was challenged in six mice as control infection. Mice were sacrificed and collected lungs at 1 days after challenge, then CD11b positive cells were isolated from the lungs of these mice. These cells were used for the analysis of microarray.
Contributor(s) Iwata-Yoshikawa N, Uda A, Sato Y, Tsunetsugu-Yokota Y, Morikawa S, Tashiro M, Sata T, Hasegawa H, Nagata N
Citation(s) 24850731
Submission date Sep 13, 2013
Last update date Feb 02, 2018
Contact name Naoko Iwata-Yoshikawa
Organization name National institute of infectious diseases
Department Pathology
Street address 1-23-1 Toyama
City Shinnjuku-ku
State/province Tokyo
ZIP/Postal code 162-8640
Country Japan
Platforms (1)
GPL10787 Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version)
Samples (24)
GSM1231170 SARSmus, UV-V, MEM, PM, 1dpi, 01
GSM1231171 SARSmus, UV-V, MEM, PM, 1dpi, 02
GSM1231172 SARSmus, UV-V, MEM, PM, 1dpi, 03
BioProject PRJNA219175

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Supplementary file Size Download File type/resource
GSE50855_RAW.tar 76.6 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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