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Series GSE50794 Query DataSets for GSE50794
Status Public on Jul 01, 2014
Title GEMM CRC collection analysis
Organism Mus musculus
Experiment type Expression profiling by array
Summary A collection of genetically engineered mouse models (GEMM) of colorectal cancer (CRC) were created, and primary tumors from these GEMMs were analyzed.
Primary CRC tumors from these GEMMs were genotyped to confirm that they contain the core genetic lesions of interest, including APC, P53, KRAS, and BRAF. Primary tumors from GEMMs with combinations of lesions of interest were analyzed by whole genome expression, and their expression profiles were compared to determine how they segregate. Signatures were then generated from GEMM tumors of interest and compared to human clinical datasets with expression and outcome data.
 
Overall design Primary tumors from CRC GEMMs with different combinations of mutant alleles of interested were generated and analyzed. Alleles include mutant forms of APC (A), P53 (P), KRAS (K) and BRAF (B).
 
Contributor(s) Belmont P, Budinska E
Citation(s) 24742783
Submission date Sep 11, 2013
Last update date Feb 11, 2019
Contact name Peter J Belmont
Organization name Pfizer
Street address 10724 Science Center Drive
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (60)
GSM1229375 A54
GSM1229376 G40
GSM1229377 A65
Relations
BioProject PRJNA218937

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50794_RAW.tar 246.0 Mb (http)(custom) TAR (of CEL)
GSE50794_data_multivariate.xls.gz 3.7 Mb (ftp)(http) XLS
Raw data provided as supplementary file
Processed data included within Sample table

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