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Series GSE50108 Query DataSets for GSE50108
Status Public on Aug 13, 2014
Title Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-Longterm-HCC1954-SKBR3]
Organism Homo sapiens
Experiment type Protein profiling by protein array
Summary EGFR-inhibition is required for targeted therapies of ERBB2-positive/EGFR high breast cancer.
Approximately 30% of human ERBB2-positive breast tumors also express EGFR.
 
Overall design Three therapeutics were analyzed in five combinations plus control. Each experiment was performed in three biological replicates. This resulted in 180 samples. Exceptionally, time point 18 has just two biological replicates, and time point 48 just one. A dilution series of control lysated was included as control.
 
Contributor(s) Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger HA, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beissbarth T, Korf U
Citation(s) 24970389
Submission date Aug 22, 2013
Last update date Aug 13, 2014
Contact name Ulrike Korf
E-mail(s) u.korf@dkfz.de
Phone 0049 (0) 6221 424765
Fax 0049 (0) 6221 423454
Organization name German Cancer Research Center
Department Molecular Genome Analysis
Street address Im Neuenheimer Feld 580
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (1)
GPL15318 Targeted array-based proteomics [RPPA-Longterm]
Samples (19)
GSM1214273 Longterm_HCC1954-SKBR3_pERK1/2_T202Y204
GSM1214274 Longterm_HCC1954-SKBR3_pAKT_S473
GSM1246944 Longterm_HCC1954-SKBR3_BAX_none
This SubSeries is part of SuperSeries:
GSE50109 Targeted inhibition of three human breast cancer cell lines as model systems of ERBB2-positive breast cancer
Relations
BioProject PRJNA216095

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50108_Long_HCC1954-SKBR3_FCF_p38_cRAF_NFkB_GSK3.gpr.gz 62.2 Kb (ftp)(http) GPR
GSE50108_Long_HCC1954-SKBR3_FCF_p53_cJUN_PTEN_ERBB2_TSC2.gpr.gz 60.1 Kb (ftp)(http) GPR
GSE50108_Long_HCC1954-SKBR3_FCF_p70S6K_CyclinD1_CyclinB1_PRAS_BAX_FoxO13a_ERBB1_ERBB3.gpr.gz 60.6 Kb (ftp)(http) GPR
GSE50108_Longterm_HCC1954-SKBR3_FCF_pAKT-9271.gpr.gz 62.1 Kb (ftp)(http) GPR
GSE50108_Longterm_HCC1954-SKBR3_FCF_pERK-4370.gpr.gz 60.5 Kb (ftp)(http) GPR
GSE50108_RAW.tar 1.2 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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