|
| Status |
Public on Aug 01, 2013 |
| Title |
Co-regulated gene expression by estrogen receptor-a and liver receptor homolog-1 is a feature of the estrogen response in breast cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Our findings establish a key role for LRH-1 in the regulation of ERa target genes in breast cancer cells and identify a mechanism in which co-operative binding of LRH-1 and ERa at estrogen response elements controls the expression of estrogen responsive g
|
| |
|
| Overall design |
Examination of ERα, with or without LRH-1 knockdown, and HA-LRH-1 in MCF-7 cells
|
| |
|
| Contributor(s) |
Flach K, Zwart W, Ali S, Velds A, Buluwela L |
| Citation(s) |
24049078 |
| |
| Submission date |
Jul 31, 2013 |
| Last update date |
Mar 04, 2020 |
| Contact name |
Koen Flach |
| E-mail(s) |
koenflach@hotmail.com
|
| Organization name |
NKI
|
| Street address |
Plesmanlaan 121
|
| City |
Amsterdam |
| ZIP/Postal code |
1066CX |
| Country |
Netherlands |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (6)
|
| GSM1198711 |
Chromatin IP for ERα in MCF-7 cells transfected with a control siRNA Replicate 1 |
| GSM1198712 |
Chromatin IP for ERα in MCF-7 cells transfected with a LRH-1 siRNA Replicate 1 |
| GSM1198713 |
Chromatin IP for ERα in MCF-7 cells transfected with a control siRNA Replicate 2 |
| GSM1198714 |
Chromatin IP for ERα in MCF-7 cells transfected with a LRH-1 siRNA Replicate 2 |
| GSM1198715 |
Chromatin IP for HA in MCF-7 cells transfected with pcDNA vector Replicate 2 |
| GSM1198716 |
Chromatin IP for HA in MCF-7 cells transfected with HA-LRH1 vector Replicate 2 |
|
| Relations |
| BioProject |
PRJNA213858 |
| SRA |
SRP028353 |
Less...
More...