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Series GSE49320 Query DataSets for GSE49320
Status Public on May 20, 2014
Title Genome-wide map of GATA6 DNA binding in human CRC cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We describe the genome-wide DNA-binding of GATA6 in a human CRC cell line (LS174T). GATA6 is found to bind the promoter of genes involved in the maintenance of intestinal stem cells, including genes of the Wnt and TGFbeta/BMP pathways. With this we describe a novel GATA6-dependent mechanism of stem cell maintenance in colorectal tumors.
Overall design Examination of GATA6 binding and H3K4me1, H3K4me3 and H3K27ac levels in a human CRC cell line by Chromatin immunoprecipitation followed by deep sequencing.
Contributor(s) Martinelli P, Whissel G, Carrillo de Santa Pau E, Vicent GP, Stephan-Otto Attolini C, Real FX, Batlle E
Citation(s) 24952462
Submission date Jul 29, 2013
Last update date May 15, 2019
Contact name Camille Stephan Otto Attolini
Organization name IRB Barcelona
Department Biostatistics and bioinformatics Unit
Street address Baldiri Reixac 10
City Barcelona
State/province Select a State or Province
ZIP/Postal code 08028
Country Spain
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (7)
GSM1197320 LS174T, GATA6 ChIP-seq 1
GSM1197321 LS174T, GATA6 ChIP-seq 2
GSM1197322 LS174T, GATA6 ChIP-seq 3
This SubSeries is part of SuperSeries:
GSE56897 The transcription factor GATA6 allows self-renewal of colon adenoma stem cells by repressing BMP gene expression
BioProject PRJNA213625
SRA SRP028302

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SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE49320_RAW.tar 2.2 Mb (http)(custom) TAR (of BEDGRAPH)
GSE49320_Sample_LS174T-GATA6.wig.gz 18.8 Mb (ftp)(http) WIG
GSE49320_Sample_LS174T-GATA6_peaks.bed.gz 141.8 Kb (ftp)(http) BED
GSE49320_Sample_LS174T-INPUT.wig.gz 19.0 Mb (ftp)(http) WIG
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
Processed data provided as supplementary file

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