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Series GSE49224 Query DataSets for GSE49224
Status Public on Jul 26, 2013
Title ChIP-Seq for transcriptional regulators and RNA Polymerase II in tumor cells treated with JQ1
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary ChIP-Seq of RNA Polymerase II, and transcriptional regulators in multiple myeloma (MM.1S), glioblastoma (U87-MG), and small cell lung carcinoma (H2171) treated with the BET bromodomain inhibitor JQ1.
 
Overall design Cell lines (MM.1S, U87-MG, and H2171) representing multiple myeloma, glioblastoma, and small cell lung carcinoma, were treated with varying concentrations (5nM to 5µM) of the BET bromodomain inhibitor JQ1 followed by ChIP-Seq for RNA Polymerase II and transcriptional regulators.  Other datasets from this series of experiments have been release as a part of GSE42355.
 
Contributor(s) Hoke H, Lars A, Sigova AA, DAlessio A, Young RA
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Submission date Jul 25, 2013
Last update date May 15, 2019
Contact name Richard A Young
E-mail(s) young_computation@wi.mit.edu
Phone 617-258-5219
Organization name Whitehead Institute for Biomedical Research
Lab Young Lab
Street address 9 Cambridge Center
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (20)
GSM1195551 U87_BRD4_DMSO_ChipSeq
GSM1195552 U87_BRD4_JQ1_ChipSeq
GSM1195553 U87_POL2_DMSO_ChipSeq
Relations
BioProject PRJNA213310
SRA SRP028248

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49224_RAW.tar 22.6 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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