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Series GSE49050 Query DataSets for GSE49050
Status Public on Jul 23, 2014
Title Expression data from postnatal mouse brain regions of Ts1Cje and disomic C57BL/6 mice.
Organism Mus musculus
Experiment type Expression profiling by array
Summary The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the MMU16 segment on global gene expression in the cerebral cortex, cerebellum and hippocampus of Ts1Cje mice at 4 time-points; postnatal day (P)1, P15, P30 and P84.
 
Overall design RNA was extracted from thre brain regions (Cerebral cortex, hippocampus and cerebellum) for hybridization to arrays from 3 pairs of Ts1Cje and disomic C57BL/6 littermate control for each timepoints at postnatal (P) day 1, P15, P30 and P84.
 
Contributor(s) Ling K, Hewitt CA, Tan K, Cheah P, Simpson K, Hyde L, Smyth GK, Thomas T, Scott HS
Citation(s) 25052193
Submission date Jul 19, 2013
Last update date Feb 11, 2019
Contact name King Hwa Ling
E-mail lkh@upm.edu.my
Phone +603-89472564
Organization name Universiti Putra Malaysia
Department Department of Biomedical Science
Lab NeuroBiology and Genetics Group
Street address Faculty of Medicine and Health Sciences
City UPM Serdang
State/province Selangor
ZIP/Postal code 43400
Country Malaysia
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (72)
GSM1193014 Wildtype P1 hippocampus biological replicate 1
GSM1193015 Ts1Cje P84 cerebral cortex biological replicate 1
GSM1193016 Ts1Cje P30 cerebral cortex biological replicate 1
Relations
BioProject PRJNA212783

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Supplementary file Size Download File type/resource
GSE49050_RAW.tar 266.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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