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| Status |
Public on Feb 03, 2015 |
| Title |
Global gene expression in the adult Gata6 null mouse pancreas |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the global gene expression of mouse pancreatic cells in a pancreas-specific conditional knock-out mouse for Gata6, as compared with age-matched controls. Total RNA was extracted from the pancreas of 6-8 -week old mice of the two genotypes and analyzed. at this age, Gata6P-/- pancreata are histologically normal, but the acinar differentiation programme is already altered. we observe that loss of Gata6 causes the de-repression of ectopic non-pancreatic genes, as well as some genes involved in the mesenchymal programme.
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| Overall design |
mRNA extracted from the pancreas of 4 controls and 4 Gata6P-/- mice was sequenced.
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| |
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| Contributor(s) |
Martinelli P, Carrillo de Santa Pau E, Real FX |
| Citation(s) |
25596178 |
| |
| Submission date |
May 30, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Enrique Carrillo de Santa Pau |
| E-mail(s) |
enrique.carrillo@imdea.org
|
| Organization name |
Spanish National Cancer Research Centre (CNIO)
|
| Department |
Cancer Cell Biology Programme
|
| Lab |
Epithelial Carcinogenesis group
|
| Street address |
C/ Melchor Fernández Almagro, 3
|
| City |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA205991 |
| SRA |
SRP023469 |
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