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Series GSE47535 Query DataSets for GSE47535
Status Public on Feb 03, 2015
Title Genome-wide map of GATA6 DNA binding in human PDAC cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide DNA-binding of GATA6 in a human PDAC cell line (PaTu8988S). GATA6 is found to bind the promoter of genes involved in the epithelial differentiation programme, as well as of genes involved in the mesenchymal programme. With this we describe a novel GATA6-dependent mechanism of regulation of EMT.
Overall design Examination of GATA6 binding to the DNA in a human PDAC cell line
Contributor(s) Martinelli P, Carrillo de Santa Pau E, Real FX
Citation(s) 25596178
Submission date May 30, 2013
Last update date May 15, 2019
Contact name Enrique Carrillo de Santa Pau
Organization name Spanish National Cancer Research Centre (CNIO)
Department Cancer Cell Biology Programme
Lab Epithelial Carcinogenesis group
Street address C/ Melchor Fernández Almagro, 3
City Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
Samples (2)
GSM1151694 GATA6 ChIP-seq
GSM1151695 input DNA
This SubSeries is part of SuperSeries:
GSE47537 Gata6
BioProject PRJNA205985
SRA SRP023467

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47535_RAW.tar 23.0 Mb (http)(custom) TAR (of TXT, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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