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Series GSE4745 Query DataSets for GSE4745
Status Public on May 08, 2006
Title Expression data from Rat ventricles 3 days/28 days/42 days after STZ injection
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Cardiomyopathy in type 1 diabetic patients is characterized by early onset diastolic and late onset systolic dysfunction. The mechanism underlying development of diastolic and systolic dysfunction in diabetes remains unknown.
We used microarrays to detail the ventricle gene expression changes that underly development of diabetic cardiomyopathy. We identified distinct classes of up-regulated genes during this process.
Keywords: disease state analysis, time course
Overall design 150g male Wistar rats (Harlan) we injected with 65 mg/kg streptozotocin to induce Type 1 diabetes. Four replicates of Control and Diabetic rat ventricles were removed and frozen at Three time points for total RNA isolation and hybridization on the Affymetrix RG-U34A microarray. The 3 day samples show a baseline for initial diabetic changes in the ventricle. The 28 day samples show changes associated with diastolic dysfunction in diabetes. The 42 day samples show changes associated with both diastolic and systolic dysfunction in type 1 diabetic rat ventricles.
Contributor(s) Gerber LK, Aronow BJ, Matlib MA
Citation(s) 16855217
Submission date May 01, 2006
Last update date Feb 21, 2017
Contact name Mohammed Abdul Matlib
Organization name University of Cincinnati
Department Pharmacology and Cell Biophysics
Street address PO Box 670575
City Cincinnati
State/province OH
ZIP/Postal code 45267-0575
Country USA
Platforms (1)
GPL85 [RG_U34A] Affymetrix Rat Genome U34 Array
Samples (24)
GSM107412 Rat_Ventricle_Control_03days_rep1
GSM107413 Rat_Ventricle_Control_03days_rep2
GSM107414 Rat_Ventricle_Control_03days_rep3
BioProject PRJNA95689

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE4745_RAW.tar 45.4 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file

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