|
| Status |
Public on Mar 12, 2015 |
| Title |
Ablation of Pten and Smad4 leads to metastatic lung carcinoma in a murine model. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Lung cancer is the leading cause of cancer related death in both men and women in the United States. Recently, Smad4 was discovered to be common somatic alteration in human squamous cell lung cancer. Our goal was to delineate the role of Smad4 in lung cancer. We have shown for the first time that the ablation of Pten and Smad4 in the murine airway epithelium harbors a metastatic proximal adeno-squamous lung cancer.
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| |
|
| Overall design |
knockout group (PTENd/d and SMAD4d/d) and control group
|
| |
|
| Contributor(s) |
Akkanti B, Zhang Y, Demayo F, Creighton C |
| Citation(s) |
25753424 |
| |
| Submission date |
May 20, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
| GSM1145192 |
lung tumors from mice with knock out of SMAD4 and PTEN rep1 |
| GSM1145193 |
lung tumors from mice with knock out of SMAD4 and PTEN rep2 |
| GSM1145194 |
lung tumors from mice with knock out of SMAD4 and PTEN rep3 |
|
| Relations |
| BioProject |
PRJNA203655 |
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