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Series GSE46723 Query DataSets for GSE46723
Status Public on Jul 01, 2013
Title Expression data from adult Myeloerythroid Progenitors (MP) Hes1-GFP positive and adult Myeloerythroid Progenitors (MP) Hes1-GFP negative
Organism Mus musculus
Experiment type Expression profiling by array
Summary Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the majority of studies in the hematopoietic system focused on Notch signaling in lymphocyte differentiation and knowledge of individual Notch receptor roles in early hematopoiesis has been limited due to a paucity of genetic tools available To fate-map Notch receptor expression and pathway activity in the hematopoietic system we used tamoxifen-inducible CreER knock-in mice for individual Notch receptors in combination to a novel Notch reporter strain (Hes1GFP) and a conditional gain of function allele of Notch2 receptor (Rosa-lsl-ICN2).
 
Overall design Bone marrow lineage negative, cKit+, Sca1- cells were sorted from Hes-GFP mice for RNA extraction and hybridization on Affymetrix microarrays
 
Contributor(s) Lobry C, Oh P, Aifantis I
Citation(s) 23791481
Submission date May 08, 2013
Last update date Feb 11, 2019
Contact name Camille Lobry
E-mail(s) camille.lobry@inserm.fr
Organization name Inserm
Department IRSL Inserm U944 / CNRS UMR7212
Lab Lobry lab
Street address 16 rue de la Grange aux Belles
City Paris
ZIP/Postal code 75010
Country France
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM1136138 adult Myeloerythroid Progenitors (MP) HES1-GFP negative replicate 1
GSM1136139 adult Myeloerythroid Progenitors (MP) HES1-GFP negative replicate 2
GSM1136140 adult Myeloerythroid Progenitors (MP) HES1-GFP negative replicate 3
This SubSeries is part of SuperSeries:
GSE46726 In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis
Relations
BioProject PRJNA202199

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46723_RAW.tar 23.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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