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| Status |
Public on May 21, 2015 |
| Title |
Expression data from MDA-MB-231 cells treated with vehicle or YW3-56 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
PAD4 is overexpressed in many cancer cells. We developed PAD inhibitors that efficiently inhibit the cancer cell growth. One inhibitor YW3-56 could efficently induce cell death of triple negative breast cancer MDA-MB-231 cells.
We used microarray to detail the global gene expression of MDA-MB-231 before and after YW3-56 treatment and identify significant up-regulated or down-regulated genes by YW3-56
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| |
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| Overall design |
MDA-MB-231 cells were cultured and treated with vehicle (DMSO) or YW3-56. Cells were washed with PBS and harvested for RNA extraction and hybridization on Affymetrix microarry.
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| |
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| Contributor(s) |
Wang S, Li P, Wang Y |
| Citation(s) |
25612620 |
| |
| Submission date |
May 02, 2013 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Yanming Wang |
| Organization name |
The Penn State University
|
| Street address |
454 North Frear Building
|
| City |
University Park |
| State/province |
Pennsylvania |
| ZIP/Postal code |
16802 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM1132974 |
MDA-MB-231 control sample, biological rep1 |
| GSM1132975 |
MDA-MB-231 control sample, biological rep2 |
| GSM1132976 |
MDA-MB-231 control sample, biological rep3 |
| GSM1132977 |
MDA-MB-231 YW3-56 treated sample, biological rep1 |
| GSM1132978 |
MDA-MB-231 YW3-56 treated sample, biological rep2 |
| GSM1132979 |
MDA-MB-231 YW3-56 treated sample, biological rep3 |
|
| Relations |
| BioProject |
PRJNA201057 |
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