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| Status |
Public on Sep 23, 2013 |
| Title |
Expression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Recent work using mouse models has revealed that mTORC2, which unlike mTORC1 is not acutely sensitive to rapamycin, plays a key role in the regulation of organismal physiology. The substrates and pathways regulated by mTORC2 are at present relatively unknown
Using a mouse model with a targeted deletion of hepatic RICTOR, we investigated the loss of mTORC2 on the murine liver transcriptome
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| Overall design |
Rictor floxed (RKO) and control mice (n=4 per group) were fasted overnight, refed for 3 hr, then sacrificed. Livers were removed, rinsed in PBS, and flash frozen in liquid nitrogen. RNA was extracted and hybridized to Affymetrix Genechip Mouse Gene 1.0 ST arrays
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| Contributor(s) |
Lamming DW, Boylan JM, Sabatini DM, Gruppuso PA |
| Citation(s) |
24072782 |
| |
| Submission date |
Apr 30, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Joan M Boylan |
| Organization name |
Rhode Island Hospital
|
| Department |
Pediatrics
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| Lab |
Endocrinology
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| Street address |
593 Eddy Street
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| City |
Providence |
| State/province |
RI |
| ZIP/Postal code |
02903 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA200711 |
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