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Series GSE46298 Query DataSets for GSE46298
Status Public on Oct 01, 2013
Title Whole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Organism Mus musculus
Experiment type Expression profiling by array
Summary Microarray analysis has been applied to the study of ALS in order to investigate gene expression in whole spinal cord homogenates of SOD1 G93A mice and human ALS cases, although the massive presence of glial cells and inflammatory factors has made it difficult to define which gene expression changes were motor neuron specific. Recently, laser capture microdissection (LCM), combined with microarray analysis, has allowed the identification of motor neuron specific changes in gene expression in mouse and human ALS cases.
The aim of the present study is to combine LCM and microarray analysis to compare the gene expression profiles of motor neurons from two SOD1G93A mouse strains (129Sv and C57) with different progression of the disease in order to discover the molecular mechanisms that may contribute to the distinct phenotypes and to uncover factors underlying fast and slow disease progression
Overall design Motor neurons have been isolated from the spinal cord of 129SvG93A mice, C57G93A mice and non transgenic littermates at different time points and the transcription expression profile of the isolated motor neurons has been analysed
Contributor(s) Nardo G, Iennaco R, Fusi N, Heath P, Marino M, Ferraiuolo L, Lawrence N, Shaw PJ, Bendotti C
Citation(s) 24065725
Submission date Apr 23, 2013
Last update date Feb 11, 2019
Contact name giovanni nardo
Organization name IRCCS-Mario Negri Institute
Street address Via La Masa 19
City Milan
ZIP/Postal code 20156
Country Italy
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (64)
GSM1128295 129Sv.G93A 56 days sample 1
GSM1128296 129Sv.G93A 56 days sample 2
GSM1128297 129Sv.G93A 56 days sample 3
BioProject PRJNA198650

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Supplementary file Size Download File type/resource
GSE46298_RAW.tar 200.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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