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| Status |
Public on May 18, 2013 |
| Title |
Impairment of Muscle Regeneration in Muscleblind-like 3 Isoform Knockout Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
We have performed an RNA-seq experiment to identify expression and alternative splicing differences between WT and Mbnl3 isoform knockout mice E15 forelimbs. We have also identified and characterized transcriptome wide Mbnl3-binding sites in C2C12 cells and E15 forelimbs.
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| Overall design |
6 total samples were analyzed: E15 forelimbs from 3 WT and 3 MBNL3 ΔE2/ΔE2 female mice (15dpc). For HITS-CLIP, 3 samples each of C2C12 cells, WT E15 forelimbs and Mbnl3 ?E2 forelimbs were analyzed for Mbnl3 binding site analysis.
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| Contributor(s) |
Ranjan B, Chaolin Z |
| Citation(s) |
23660517 |
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| Submission date |
Apr 18, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Ranjan Batra |
| E-mail(s) |
ranjanbatra9@yahoo.com
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| Phone |
352-222-9209
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| Organization name |
University of California San Diego
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| Department |
Cellular and Molecular Medicine
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| Lab |
Yeo Lab
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| Street address |
2880 Torrey Pines Scenic Drive
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| City |
La Jolla |
| State/province |
California |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (15)
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| GSM1126332 |
Mbnl3 KO, biological rep 1 |
| GSM1126333 |
Mbnl3 KO, biological rep 2 |
| GSM1126334 |
Mbnl3 KO, biological rep 3 |
| GSM1127906 |
C2C12, biological rep1 (HITS-CLIP) |
| GSM1127907 |
C2C12, biological rep2 (HITS-CLIP) |
| GSM1127908 |
C2C12, biological rep3 (HITS-CLIP) |
| GSM1127909 |
WT, biological rep1 (HITS-CLIP) |
| GSM1127910 |
WT, biological rep2 (HITS-CLIP) |
| GSM1127911 |
WT, biological rep3 (HITS-CLIP) |
| GSM1127912 |
Mbnl3 KO, biological rep1 (HITS-CLIP) |
| GSM1127913 |
Mbnl3 KO, biological rep2 (HITS-CLIP) |
| GSM1127914 |
Mbnl3 KO, biological rep3 (HITS-CLIP) |
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| Relations |
| BioProject |
PRJNA198191 |
| SRA |
SRP021195 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE46207_Mbnl3_37_C2C12_combined.bed.gz |
12.0 Mb |
(ftp)(http) |
BED |
| GSE46207_RAW.tar |
484.4 Mb |
(http)(custom) |
TAR (of BED, BEDGRAPH) |
| GSE46207_RNA-seq_Mbnl3_E15_WT_vs_KO.txt.gz |
11.6 Kb |
(ftp)(http) |
TXT |
| GSE46207_Table_1_HITS_CLIP_Summary.xls.gz |
718.3 Kb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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