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Series GSE45984 Query DataSets for GSE45984
Status Public on Apr 13, 2013
Title ChIP-Seq for cofactors in cancer
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Critical drivers of cancer progression are likely controlled through the actions of transcription factors and cofactors that bind to the genome and form enhancers that stimulate gene expression. We present ChIP-seq analysis of key transcriptional regulators, cofactors and histone modifications that indicate transcriptional activity across a range of different cancer cells.
Overall design ChIP-seq was performed against the cofactors Med1, Brd4 and CDK7 in MM1.S multiple myeloma cells; Brd4 in Sk-MEL-5 melanoma cells; and H3K9/K14 acetylation in MV4;11 leukemia cells,
Contributor(s) Lars A, DAlessio A, Young RA
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Submission date Apr 11, 2013
Last update date May 15, 2019
Contact name Richard A Young
Phone 617-258-5219
Organization name Whitehead Institute for Biomedical Research
Lab Young Lab
Street address 9 Cambridge Center
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (11)
GSM1121090 AD-MV4;11 WCE_ChipSeq
GSM1121091 AD-MV4;11_K9-K14ac_ChipSeq
GSM1121092 AD-5-Med1-3x10*6-0.1-20s_ChipSeq
SRA SRP020946
BioProject PRJNA196924

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Supplementary file Size Download File type/resource
GSE45984_RAW.tar 7.9 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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