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| Status |
Public on Aug 15, 2013 |
| Title |
Genome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 and Ezh2 targets, suggensting a Ezh2-independent manner. Further detailed study revealed that YY1 can regulate some lincRNAs which are fucntional in skeletal myogenesis. In this study, we identified a YY1-Yam-1-miR-715 (TF-lincRNA-miRNA) regulatory curcuit in myogensis.
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| Overall design |
Examination of YY1 targets in myoblast versus myotubes
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| Contributor(s) |
Wang H, Sun H, Lu L, Sun K, Chen X, Wang L, Zhao Y, Zhou L |
| Citation(s) |
23942234, 26484078 |
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| Submission date |
Apr 08, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Kun Sun |
| E-mail(s) |
sunkun@szbl.ac.cn
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| Organization name |
Shenzhen Bay Laboratory
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| Department |
Cancer Research
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| Lab |
Kun Sun
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| Street address |
Rm B505, No. 9 Duxue Road, Nanshan District
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| City |
Shenzhen |
| ZIP/Postal code |
518107 |
| Country |
China |
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| Platforms (2) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (8)
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| Relations |
| SRA |
SRP020624 |
| BioProject |
PRJNA196689 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45875_RAW.tar |
380.0 Kb |
(http)(custom) |
TAR (of BEDGRAPH, TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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