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Series GSE45577 Query DataSets for GSE45577
Status Public on Aug 16, 2013
Title Profiling of glycerol- and CTX-induced models of muscle regeneration in mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Utilizing glycerol and cardiotoxin (CTX) injections in the tibialis anterior muscles of M. musculus provides models of skeletal muscle damages followed by skeletal muscle regeneration. In particular, glycerol-induced muscle regeneration is known to be associated with ectopic adipogenesis. We characterized genome-wide expression profiles of tibialis anterior muscles from wild-type mice injured by either glycerol or CTX injection. Our goal was to detect gene expression changes during the time course of glycerol-induced and CTX-induced muscle regeneration models, that can lead to ectopic adipocyte accumulation.
 
Overall design Tibialis anterior muscle of 12 week old wildtype C57BL/6J male mice injected i.m with either glycerol or CTX were collected 3, 7, 14 or 21 days after injection. 6 biological replicates were used for each time points.
Please note that a few replicate samples did not pass QC test, thus, were removed from the submission.
Unchallenged tibialis anterior muscles from a group of 5 wildtype C57BL/6J mice were also as a control. Total RNA was extracted, QCed and hybridized to Affymetrix microarrays.
 
Contributor(s) Lukjanenko L, Feige JN, Brachat S
Citation(s) 23976982
Submission date Mar 28, 2013
Last update date Feb 11, 2019
Contact name Sophie Brachat
E-mail sophie.lemire@novartis.com
Organization name Novartis Institutes For Biomedical Research
Department Muskuloskeletal
Street address Novartis Campus
City Basel
ZIP/Postal code CH-4002
Country Switzerland
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (48)
GSM1109954 272_01
GSM1109955 272_02
GSM1109956 272_03
Relations
BioProject PRJNA194615

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45577_RAW.tar 175.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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