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Series GSE45201 Query DataSets for GSE45201
Status Public on Mar 16, 2013
Title Amplitude modulation of androgen signaling by c-MYC [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Androgen-stimulated growth of the molecular apocrine breast cancer is mediated by an androgen receptor (AR)-regulated transcriptional program. Through profiling the genomic licalizations of AR and its co-regulators FOXA1 and TCF7L2 in MDA-MB-453 breast cancer cells, we revealed the molecular details of the AR-centered regulatory network. We further identified that c-MYC is a key downstream target co-regulated by AR, FOXA1 and TCF7L2, and reinforces the transctiopnal activation of androgen-responsive genes in this subtype of breast cancers.
Overall design AR and FOXA1 ChIP-seq were performed in MDA-MB-453 breast cancer cells with treatment of 5a-dihydrotestosterone (DHT) for 16 h. TCF7L2 ChIP-seq was performed in MDA-MB-453 cells treated with vehicle or DHT for 16 h, respectively. MYC ChIP-seq was performed in MDA-MB-453 cells following 6 h DHT stimulation.
Contributor(s) Ni M, Chen Y, Brown M
Citation(s) 23530127
Submission date Mar 15, 2013
Last update date May 15, 2019
Contact name Yiwen Chen
Organization name University of Texas MD Anderson Cancer Center
Department Bioinformatics and Computational Biology
Lab Yiwen Chen
Street address 1400 Pressler Street
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM1099029 MYC ChIP-seq, 6h DHT treatment
GSM1099030 AR ChIP-seq, 16h DHT treatment
GSM1099031 FOXA1 ChIP-seq, 16h DHT treatment
This SubSeries is part of SuperSeries:
GSE45203 Amplitude modulation of androgen signaling by c-MYC
BioProject PRJNA193202
SRA SRP019497

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Supplementary file Size Download File type/resource
GSE45201_RAW.tar 550.0 Kb (http)(custom) TAR (of BED)
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Raw data are available in SRA
Processed data provided as supplementary file

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