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| Status |
Public on Mar 15, 2013 |
| Title |
linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To identify aberrantly expressed long intergenic noncoding RNAs (lincRNAs) in bladder cancer tissues compared with normal adjacent tissues, we have employed microarray expression profiling as a discovery platform to identify lincRNAs that may play important roles in bladder cancer origin and progression. Samples of fresh frozen cancer tissues, together with normal adjacent tissues (3 cm away from the tumor), were obtained during surgical resection, and total RNA was extracted for microarray analysis. Expression of six mRNAs and lincRNAs (E2F1, CCNE2, CCNB1, lincRNA:chr1:205404014-205407007, lincRNA:chr7:130723313-130727663, lincRNA:chr4:15669186-15683175) from this signature was quantified in the same RNA samples by real-time PCR, confirming good quality of the microarray analysis. Data in the matrix are log2 transformed.
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| Overall design |
Gene expression signatures for bladder cancer tissues and normal adjacent tissues.
Three pairs of fresh frozen bladder cancer tissues and corresponding normal adjacent tissues were used in the microarray analysis.
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| Contributor(s) |
He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J, Lin T |
| Citation(s) |
23688781 |
| Submission date |
Mar 14, 2013 |
| Last update date |
Oct 11, 2016 |
| Contact name |
Wang He |
| E-mail(s) |
hewang525344@126.com
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| Phone |
+86-18665599908
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| Organization name |
Sun Yat-sen Memorial Hospital
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| Department |
Urology
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| Lab |
Lin Bai-xin Medical Research Center
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| Street address |
107th, Yanjiangxi Road
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510120 |
| Country |
China |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA193171 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45184_RAW.tar |
18.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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