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Series GSE45042 Query DataSets for GSE45042
Status Public on May 03, 2013
Title Cell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Differential expression was determined in Calu-3 cells between mock infected and infection with either Human coronavirus EMC and SARS coronavirus at different times post infection.
Overall design Calu-3 2B4 cells were infected with Human Coronavirus EMC 2012 (HCoV-EMC) or mock infected. Samples were collected 0, 3, 7, 12, 18 and 24 hpi.
There are 3 mock and 3 infected replicates for each time point, except for 12 hpi for which there are only 2 infected replicates (one replicate did not pass RNA quality check). There were no mock sampes at 18 hpi, and therefore infected samples at 18 hpi were compared with mocks at 24 hpi.
For direct comparison with SARS-CoV infected cells, raw data from HCoV-EMC experiments were quantile normalized together with the SARS-CoV dataset (GEO Series accession number GSE33267).
Contributor(s) Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG
Citation(s) 23631916, 24846384
Submission date Mar 12, 2013
Last update date Jan 23, 2019
Contact name Michael Katze
Organization name University of Washington
Department Microbiology
Lab Michael G. Katze, Ph.D
Street address Rosen Building 960 Republican St.
City Seattle
State/province WA
ZIP/Postal code 98109-4325
Country USA
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (32)
GSM1096511 ECL001_Mock_12hr_1
GSM1096512 ECL001_EMC_0hr_3
GSM1096513 ECL001_EMC_24hr_2
BioProject PRJNA192892

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Supplementary file Size Download File type/resource
GSE45042_RAW.tar 285.2 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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