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Series GSE43985 Query DataSets for GSE43985
Status Public on Dec 01, 2014
Title The Estrogen receptor alpha regulated NEAT1 long non-coding RNA promotes prostate cancer progression [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Prostate glands predominantly exhibit androgen dependence, but increasing evidence suggests that estrogen receptor signaling is involved in its development and pathogenesis. By integrating ChIP sequencing for estrogen receptor alpha (ERα) with transcriptome sequencing data from prostate cancer samples, we found ERα to significantly influence the noncoding transcriptome in prostate cancer. We identified one such long noncoding RNA, NEAT1, to play an important role in prostate cancer progression through direct regulation of transcription of its target genes. NEAT1, in an ERα dependent manner, promotes prostate tumorigenesis by interacting with and modulating chromatin state at promoters of prostate cancer specific signature genes. NEAT1 expression is positively correlated with PSMA in prostate adenocarcinoma and with B3GAT1 in neuroendocrine prostate cancer. This study identifies NEAT1 as a novel biomarker or therapeutic target in prostate cancer and also suggests that co-targeting ERα and androgen receptor (AR) may be effective for a subset of patients with advanced prostate cancer and with NEAT1 overexpression.
Overall design ERa ChIP seq in 4 different cell lines
Contributor(s) Chakravarty D, Rubin MA
Citation(s) 25415230
Submission date Feb 01, 2013
Last update date May 15, 2019
Contact name Dimple Chakravarty
Phone (646)962-6189
Organization name Weill Cornell Medical College
Department Pathology
Lab BB 1450
Street address Belfer Research Building 413 E 69 St., New York
State/province NY
ZIP/Postal code 10021
Country USA
Platforms (2)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (5)
GSM1076109 VCaP [ERα_ChIP-Seq]
GSM1076110 VCaP + E2 [ERα_ChIP-Seq]
GSM1076111 VCaP ERa + E2 [ERα_ChIP-Seq]
This SubSeries is part of SuperSeries:
GSE43988 The Estrogen receptor alpha regulated NEAT1 long non-coding RNA promotes prostate cancer progression
BioProject PRJNA188302
SRA SRP018378

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43985_RAW.tar 60.0 Kb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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