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Series GSE43373 Query DataSets for GSE43373
Status Public on Jan 09, 2013
Title Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A
Organism Mus musculus
Experiment type Expression profiling by array
Summary Toll-like receptor (TLR)4 agonists are known potent immunostimulatory compounds. These compounds can be formulated as part of novel adjuvants to enhance vaccine medicated immune responses. However, the contribution of the formulation to the innate in vivo activity of TLR4 agonist compounds is not well understood.
Molecular expression profiles and cellular responses in a mouse model were used to compare for GLA-SE, GLA, Alum, SE, PBS. This study was to evaluate the mechanism of actions of different adjuvants and to identify potential biomarkers for clinical evaluation.
 
Overall design Muscle, lymphnode, and blood tissues from Balb/c mice were examined after treatments with GLA-SE, GLA, SE and Alum. A time course study at 0, 6h, day 1, day 2, and day 4 were carried out.
ACF Study No. 078-10-007 and Study No. 078-11-008
 
Contributor(s) Lambert S, Yang C, Liu Z, Sweetwood R, Zhao J, Woo J, Jin H
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Submission date Jan 09, 2013
Last update date Feb 11, 2019
Contact name Zheng Liu
Organization name Medimmune LLC
Street address One Medimmune Way
City Gaithersburg
ZIP/Postal code 20878
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (130)
GSM1061510 Blood_6 hr_GLA-SE_rep1
GSM1061511 Blood_6 hr_GLA-SE_rep2
GSM1061512 Blood_6 hr_GLA-SE_rep3
Relations
BioProject PRJNA185761

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43373_RAW.tar 332.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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