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Series GSE43326 Query DataSets for GSE43326
Status Public on Mar 22, 2013
Title Gene expression data from iPSC-derived neural cells, comparison between APP wild and E693delta mutation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Oligomeric forms of amyloid-beta peptide (Abeta) are presumed to play a pivotal role in the pathogenesis of Alzheimer’s disease (AD). However, it is still unclear how Abeta oligomers contribute to AD pathogenesis in patient neural cells. We generated induced pluripotent stem cells (iPSCs) from a familial AD patient and differentiated them into neural cells. Abeta oligomers were accumulated in neural cells of AD bearing amyloid precursor protein (APP)-E693delta mutation.
To uncover Abeta oligomers in AD(APP-E693delta) neural cells, we analyzed gene expression profiles of control and the AD neural cells
Overall design comparison between control (n=3) and AD (n=3)
Contributor(s) Inoue H, Kondo T
Citation(s) 23434393
Submission date Jan 07, 2013
Last update date Jul 26, 2018
Contact name Haruhisa Inoue
Phone +81-75-366-7036
Organization name Kyoto University
Street address 53 Kawahara-cho, Shogoin, Sakyo-ku
City Kyoto
State/province Kyoto
ZIP/Postal code 606-8507
Country Japan
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (6)
GSM1060531 iPSdN_APPWild_1_N116213
GSM1060532 iPSdN_APPWild_2_N117322
GSM1060533 iPSdN_APPWild_3_409B2
BioProject PRJNA185778

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43326_RAW.tar 22.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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