|
| Status |
Public on Apr 23, 2013 |
| Title |
Genome-wide maps of Sox/Oct partnerships pluripotent and lineage-committed cells |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We show here by using genome-wide ChIP-sequencing that lineage segregation involves multiple Sox/Oct partnership. In undifferentiated ES cells Oct4 interacts with Sox2 and both TFs bind on the 'canonical' motif, whereas in cells commited to PrE lineage Oct4 switches from Sox2 to Sox17 interaction and this complex bind to a unique "compressed" motif.
|
| |
|
| Overall design |
ChIP-sequencing has been done for Sox2, Sox17 and Oct4 in the pluripotent context or PrE context
|
| |
|
| Contributor(s) |
Aksoy I, Stanton L |
| Citation(s) |
23474895 |
| |
| Submission date |
Jan 03, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Irene Aksoy |
| E-mail(s) |
irene.aksoy@inserm.fr
|
| Organization name |
Stem Cell and Brain Research Institute
|
| Street address |
18 avenue du Doyen Lepine
|
| City |
Lyon |
| ZIP/Postal code |
69500 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (20)
|
|
| Relations |
| SRA |
SRP017766 |
| BioProject |
PRJNA185339 |
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