|
| Status |
Public on May 15, 2013 |
| Title |
Usp22 depletion in E14 mouse ESCs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mouse ESCs depleted of the epigenetic modifying enzyme Usp22 fail to differentiate properly. Ectopic expresison of Usp22 results in spontaneous differnetiation.
In order to understand the transcriptional program underlying this biological defect, whole genome expression analysis was performed.
|
| |
|
| Overall design |
E14 mESCs were infected with lentivirus containing shRNA targeting Usp22 or control (Luc). RNA was extracted from both samples and subjected to expression analysis by affymetrix array.
|
| |
|
| Contributor(s) |
Sussman RT, McMahon SB |
| Citation(s) |
23760504 |
| |
| Submission date |
Dec 14, 2012 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Steven B McMahon |
| E-mail(s) |
steven.mcmahon@jefferson.edu
|
| Organization name |
Thomas Jefferson University
|
| Department |
Cancer Biology
|
| Lab |
McMahon
|
| Street address |
233 S. 10th st. room 609
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19107 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA183889 |
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