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Series GSE42904 Query DataSets for GSE42904
Status Public on Dec 08, 2015
Title Reduced adult neurogenesis and neuronal abnormalities in the hippocampus underlie cognitive deficiency following prenatal administration of the anti-epileptic drug valproic acid
Organism Mus musculus
Experiment type Expression profiling by array
Summary Prenatal exposure to valproic acid, an established anti-epileptic drug, has been reported to impair postnatal cognitive function of children from epileptic mothers. Nevertheless, its pathology and proper treatment to minimize the effects remain unknown. In mice, we found that the postnatal cognitive function impairment was mainly caused by a reduction of adult neurogenesis and abnormal neuronal features in the hippocampus, which could be ameliorated by voluntary running.
 
Overall design Pregnant mice received an oral administration of methylcellulose (MC), valproic acid (VPA) or valpromide (VPM) once a day on three consecutive embryonic days (E) 12.5, E13.5, and E14.5 and were sampled 3hr after the last administration (E14.5), at E18.5, and at 12 weeks of age.
 
Contributor(s) Juliandi B, Igarashi K, Nakashima K
Citation(s) 26677766
Submission date Dec 13, 2012
Last update date Feb 11, 2019
Contact name KATSUHIDE IGARASHI
E-mail k-igarashi@hoshi.ac.jp
Phone +81-3-3786-1011
Organization name Hoshi University School of Pharmacy and Pharmaceutical Science
Department Life Science Tokyo Advanced Research center (L-StaR)
Street address 2-4-41 Ebara
City Shinagawa-ku
State/province Tokyo
ZIP/Postal code 142-8501
Country Japan
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (59)
GSM1053095 E14, MC, biological rep1
GSM1053096 E14, MC, biological rep2
GSM1053097 E14, MC, biological rep3
Relations
BioProject PRJNA183837

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42904_RAW.tar 1023.0 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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