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Series GSE42606 Query DataSets for GSE42606
Status Public on May 01, 2014
Title Genome-wide transcriptional profiling of human PBMCs stimulated with Candida albicans and non-fungal inflammatory stimuli
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections, but human anti-fungal immunity remains poorly defined. Expression profiling of Candida-stimulated human peripheral blood mononuclear cells (PBMCs) provides new insights into Candida-specific host defense mechanisms in humans.
 
Overall design Total RNA was extracted from PBMCs from healthy human volunteers. PBMCs were stimulated with heat-killed Candida albicans (10^6/ml), non-fungal inflammatory stimuli or RPMI control for 4 or 24 hours. A large number of biological replicates (>20) were included per stimulation condition and duration.
 
Contributor(s) Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ
Citation(s) 23299892
Submission date Nov 28, 2012
Last update date Aug 13, 2018
Contact name Aylwin Ng
Organization name CCIB, MGH
Street address 185 Cambridge Street
City Boston
State/province MA
ZIP/Postal code 02114
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (299)
GSM1046499 PBMC stimulated with Borrelia 4h, rep1
GSM1046500 PBMC stimulated with Borrelia 4h, rep2
GSM1046501 PBMC stimulated with Borrelia 4h, rep3
Relations
BioProject PRJNA182378

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42606_RAW.tar 26.2 Mb (http)(custom) TAR
GSE42606_non-normalized.txt.gz 51.9 Mb (ftp)(http) TXT
Processed data included within Sample table
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