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Series GSE42592 Query DataSets for GSE42592
Status Public on Nov 28, 2012
Title Alterations in gene expression in Caenorhabditis elegans associated with exposure to several classes of toxic industrial chemicals/materials.
Organism Caenorhabditis elegans
Experiment type Expression profiling by array
Summary Effective toxicological testing of the vast number of new and existing chemicals currently in use will require efficient and cost effective methods. We evaluated the utility of a simple, low cost toxicity testing system employing the nematode Caenorhabditis elegans to identify toxicologically relevant changes in gene expression.
The objective of this research is to determine genomic and proteomic responses in the model nematode C. elegans to exposures to representatives of several classes of toxic industrial chemicals/materials (TICs/TIMs). A total of 3 chemicals (acrylamide, cadmium chloride, and mercuric chloride) were used in these experiments. Affymetrix GeneChip for C. elegans was used to examine genome-wide responses in the 19,000+ genes of this model organism.
Overall design Mid-vulval L4 worms were exposed to one of four concentrations of acrylamide, cadmium or mercury for 4h and 8h. Exposures were performed in triplicate.
Contributor(s) Jackson DA, Lewis JA, Clegg ED, Szilagyi M, Gehman EA
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Submission date Nov 28, 2012
Last update date Jul 06, 2016
Contact name John A. Lewis
Organization name U.S. Army Center for Environmental Health Research
Department Biomarkers Program
Street address 568 Doughten Drive
City Ft. Detrick
State/province MD
ZIP/Postal code 21702-5010
Country USA
Platforms (1)
GPL200 [Celegans] Affymetrix C. elegans Genome Array
Samples (80)
GSM1045580 acrylamide_control_expose-0h_rep1
GSM1045581 acrylamide_control_expose-4h_rep1
GSM1045582 acrylamide_low_expose-4h_rep1
BioProject PRJNA182325

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42592_RAW.tar 770.7 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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