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Series GSE42161 Query DataSets for GSE42161
Status Public on Nov 30, 2012
Title Chromatin occupancy of key transcriptional regulators in the presence of the BET bromodomain inhibitor JQ1
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary MM1.S cells are an aggressive dexamethasone sensitive multiple myeloma cell line whose transcritional program is driven by deregulated c-Myc activity. We present ChIP-seq analysis of key transcritional regulators that are implicated the c-Myc transcriptional network in MM1.S cells treated with vehicle or 500nM JQ1.
Overall design Brd4, Cdk9, cMyc, Max, Med1, RNA Pol II, and the chromatin modifications H3K4me3 and H3K27Ac were profiled in MM1.S cells treated with 500nM JQ1 for 24hr
Contributor(s) Peter R, Loven J, Young RA
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Submission date Nov 08, 2012
Last update date May 15, 2019
Contact name Richard A Young
Phone 617-258-5219
Organization name Whitehead Institute for Biomedical Research
Lab Young Lab
Street address 9 Cambridge Center
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (13)
GSM1033752 MM.1S_Brd4_JQ1_JL_ChipSeq
GSM1033753 MM.1S_Brd4_DMSO_JL_ChipSeq
GSM1033754 MM.1S_c_Myc_JQ1_JL_ChipSeq
BioProject PRJNA179218
SRA SRP017132

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42161_RAW.tar 11.2 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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