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Series GSE41789 Query DataSets for GSE41789
Status Public on Nov 01, 2013
Title Senescence gene signature of radiation fibrosis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged animals. We demonstrate that NOX4 expression and superoxide elaboration is increased in irradiated lungs and pneumocytes in a dose dependent fashion.
We used microarrays to detail the global programme of gene expression and report that irradiated lung tissue correlates with that observed in the lungs in aged animals.
 
Overall design Female C57Bl/Ncr mice, aged 10 weeks were treated with/ without radiation to the thorax with a X-RAD 320 x-ray irradiator at a dose rate of 2.61 Gy/minute. An age-matched cohort of mice received no IR while additional cohorts received 5 Gy in a single dose, 17.5 Gy in a single dose. RNA was extracted and hybridization done on Affymetrix Mouse430_2 microarrays.
 
Contributor(s) Citrin D, Chung EJ
Citation(s) 24052614
Submission date Oct 23, 2012
Last update date Feb 11, 2019
Contact name Uma T Shankavaram
E-mail uma@mail.nih.gov
Phone 301-496-6718
Organization name NIH
Department NCI
Lab Radiation Oncology Branch
Street address 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (45)
GSM1024320 mouse lung tissue at week 2, 0 Gy, biological rep1
GSM1024321 mouse lung tissue at week 2, 0 Gy, biological rep2
GSM1024322 mouse lung tissue at week 2, 0 Gy, biological rep3
Relations
BioProject PRJNA178206

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41789_RAW.tar 176.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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