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Series GSE41667 Query DataSets for GSE41667
Status Public on Oct 11, 2015
Title Effects of TSLP challenge on airway inflammation in naïve and OVA-sensitized mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary TSLP is believed to play a role in allergic diseases such as atopic dermatitis and asthma, through its activation of dendritic cells which later promote the induction of inflammatory Th2 cells. We sought to characterize the inflammatory response induced by TSLP challenge in naive and OVA-sensitized mice using gene expression profiling.
Overall design Naïve and OVA-sensitized animals were given increasing doses of TSLP (Saline, Buffer alone, 150 ng TSLP, 500 ng TSLP and 1500 ng TSLP) and sacrificed 6 and 24 hours post-challenge. 8 animals were used for each sensitization-dose-time point combination.
Contributor(s) Cheng DT, Ravindran P, Allard J, Golji J, Bitter H, Stevenson C
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Submission date Oct 17, 2012
Last update date Feb 11, 2019
Contact name Donavan Cheng
Organization name Hoffmann-LaRoche
Department Translational Research Sciences
Street address 340 Kingsland Ave
City Nutley
State/province NJ
ZIP/Postal code 07110
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (149)
GSM1021524 A2_Saline_6 hrs
GSM1021525 A3_Saline_6 hrs
GSM1021526 A8_Saline_6 hrs
BioProject PRJNA177908

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41667_RAW.tar 600.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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