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| Status |
Public on Sep 15, 2013 |
| Title |
Distribution of insulator proteins CP190, dCTCF, Su(Hw) and Mod(mdg4)2.2 in Drosophila S2 cells in the presence or absence of dPARP inhibitor 3AB |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We mapped the localization of insulator proteins in Drosophila S2 cells in the presence or absence of 12mM of 3AB. We found that inhibition of PARylation affects DNA binding of insulator proteins only at a small subsets of genomic sites.
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| |
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| Overall design |
Examination of genomic occupancy for insulator proteins in S2 cells with or without 3AB inhibition.
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| |
|
| Contributor(s) |
Corces VG, Ong C-, Van Bortle K- |
| Citation(s) |
24055367 |
| |
| Submission date |
Oct 04, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Chin-Tong Ong |
| E-mail(s) |
chintong@tll.org.sg
|
| Organization name |
Temasek Life Sciences Lab
|
| Department |
Developmental Biology
|
| Lab |
Ong
|
| Street address |
1 Research Link
|
| City |
Singapore |
| ZIP/Postal code |
117604 |
| Country |
Singapore |
| |
|
| Platforms (1) |
| GPL13304 |
Illumina HiSeq 2000 (Drosophila melanogaster) |
|
| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE50769 |
Mapping the inter- and intra-chromosomal interactions of specific insulator binding sites with circular chromosome conformation capture (4C) assay (Gondor et al., 2008 Nature Protocol) |
|
| Relations |
| SRA |
SRP016002 |
| BioProject |
PRJNA176855 |
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