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Series GSE40531 Query DataSets for GSE40531
Status Public on Sep 01, 2012
Title Gene expression profiling of CA10 and NHD13 murine AML
Organism Mus musculus
Experiment type Expression profiling by array
Summary We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy transgenic and wildtype hematopoetic tissue to identify genes and pathways that can collaborate with these oncogenic fusion proteins to promote leukemic transformation.
Overall design CA10 and NHD13 transgenic mice were sacrificed when clinical signs of leukemia manifested (mice were hunched, skinny, or had an abnormal complete blood count). For comparsion, we harvested age matched bone marrow, thymi, and spleen from wildtype and clinically healthy trangenic tissues. Transgenic animals were considered clinically healthy if no evident signs of leukemia were present.
Contributor(s) Novak RL, Harper DP, Caudell D, Slape C, Beachy SH, Aplan PD
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Submission date Aug 31, 2012
Last update date Feb 11, 2019
Contact name Rachel Lynn Novak
Phone 301-827-2488
Organization name NCI
Street address 41 Center Drive
City Bethesda
State/province Maryland
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (57)
GSM995713 C10 CH LN BM 1
GSM995714 C10 CH LN BM 2
GSM995715 C10 CH LN BM 3
BioProject PRJNA174228

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Supplementary file Size Download File type/resource
GSE40531_RAW.tar 198.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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