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Series GSE40372 Query DataSets for GSE40372
Status Public on Aug 28, 2012
Title Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary In this work, we characterized the epigenomic integrity of 17 hiPSC lines derived from six different cell types with varied reprogramming efficiencies. We demonstrate that epigenetic aberrations are a general feature of the hiPSC state and are independent of the somatic cell source. Additionally, we determine that both shared and line-specific epigenetic aberrations in hiPSCs can directly translate into changes in gene expression in both the pluripotent and differentiated states.
Overall design Examination of differential methylation between iPSC and ESCs through differentiated states.
Examination of differential methylation between iPSC and somatic cell source and iPSC and ESCs.
Contributor(s) Plongthongkum N, Diep DH, Gore A, Fung H, Zhang K
Citation(s) 22991473
Submission date Aug 24, 2012
Last update date May 15, 2019
Contact name Kun Zhang
Organization name University of California, San Diego
Department Bioengineering
Lab Integrative Genomics Laboratory
Street address 9500 Gilman Dr Mailcode: 0412
City La Jolla
State/province CA
ZIP/Postal code 92093
Country USA
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (65)
GSM992360 ASThiPS4F5-ACTIVIN-p16
GSM992361 ASThiPS4F4-ACTIVIN-p36
GSM992362 HUVhiPS4F6-ACTIVIN-p23
SRA SRP015122
BioProject PRJNA173887

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40372_RAW.tar 344.4 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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