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Series GSE39776 Query DataSets for GSE39776
Status Public on Mar 28, 2013
Title Examination of gene expression in human placenta using RNA-seq
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). However, genomic sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. However, to date only cultured cells and some cancers have shown evidence for PMDs, suggesting that PMDs may not be observed in normal human tissues. Here we performed MethylC-seq in a set of human tissues and found that full-term human placenta shows clear evidence of PMDs.
 
Overall design Examination of gene expression in human placenta using RNA-seq, with one biological replicate (taken from same placenta)
 
Contributor(s) Schroeder DI, LaSalle JM
Citation(s) 23530188
Submission date Jul 31, 2012
Last update date May 15, 2019
Contact name Janine LaSalle
E-mail jmlasalle@ucdavis.edu
Organization name UC Davis
Street address Medical Microbiology and Immunology
City Davis
State/province CA
ZIP/Postal code 95616
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (2)
GSM978969 placenta RNA rep1
GSM978970 placenta RNA rep2
This SubSeries is part of SuperSeries:
GSE39777 Comparison of DNA methylation in human tissues
Relations
BioProject PRJNA171704
SRA SRP014635

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39776_placenta.genes.fpkm_tracking.gz 780.6 Kb (ftp)(http) FPKM_TRACKING
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Raw data are available in SRA
Processed data is available on Series record

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