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Series GSE39121 Query DataSets for GSE39121
Status Public on Jun 10, 2013
Title Lung adenocarcinoma metastasis is suppressed by the alveolar lineage transcription factors GATA6 and HOPX.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Molecular programs that mediate normal cell differentiation are required for oncogenesis and tumor cell survival in certain cancers. How cell-lineage-restricted genes specifically influence metastasis is poorly defined. In lung cancers, we uncovered a transcriptional program that is preferentially associated with distal airway epithelial differentiation and lung adenocarcinoma (ADC) progression. This program is regulated in part by the lineage transcription factors GATA6 and HOPX. These factors can cooperatively limit the metastatic competence of ADC cells, by modulating overlapping alveolar differentiation and invasogenic target genes. Thus, GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype.
Overall design mRNA profiles of human lung Adenocarcinoma PC9 cell lines infected with lentivirus harboring shRNA of control and shRNA of both GATA6 and HOPX were generated by deep sequencing, in triplicate, using Illumina HiSeq2000.
Contributor(s) Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX
Citation(s) 23707782
Submission date Jul 05, 2012
Last update date May 15, 2019
Contact name Don Nguyen
Phone 2037374514
Organization name Yale Shcool of Medicine
Street address 310 Cedar St
City New Haven
State/province CT
ZIP/Postal code 06520
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM956428 shCtrl.1
GSM956429 shCtrl.2
GSM956430 shCtrl.3
BioProject PRJNA170053
SRA SRP014027

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39121_counts_normalized_shCtrl_shGata6Hopx.txt.gz 847.9 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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