|
| Status |
Public on Dec 10, 2012 |
| Title |
CXCL12 and IGF1 select for cancer cell populations with enhanced bone metastasis ability |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
CXCL12 and IGF1 confer on cancer cells survival advantage. Src potentiates cancer cells' reponse to CXCL12 and IGF1 by strengthening AKT activation. Long-term incubation of CXCL12 and IGF1 select for cancer cells with enhanced Src activity and bone metastasis potential.
|
| |
|
| Overall design |
MDA-MB-231 cells were incubated for three weeks in growth medium of reduced serum concentration (0.2%) with or without CXCL12 (30 ng/ml) and IGF1 (10 ng/ml). Cell populations survive under these condidtions are expanded by regular growth medium with 10% serum. Two biological replicates were profiled for each condition.
|
| |
|
| Contributor(s) |
Zhang XH, Jin X, Massague J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 04, 2012 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Xiang Zhang |
| E-mail(s) |
xiangz@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Lester and Sue Smith Breast Center
|
| Lab |
Zhang
|
| Street address |
One Baylor Plaza, BCM600
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA170054 |
Less...
More...