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| Status |
Public on Aug 14, 2012 |
| Title |
Expression data of normal human extraocular muscle and strabismic human extraocular muscle |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Human strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of human EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans. Our samples are from human strabismic patients undergoing corrective surgery, and from human organ donors with no history of EOM disease.
Microarray analysis showed that 604 genes in these samples have significantly different expression. Expression was predominantly up-regulated in genes involved in extracellular matrix structure and down-regulated in genes related to contractility.
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| Overall design |
We used four normal samples and four strabismic samples. Three normal samples were from independent donors. One normal sample was a different piece of the same EOM from one of the 3 donors. All four strabismic samples were independent samples.
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| Contributor(s) |
Altick AL, Feng C, Schlauch K, Johnson LA, von Bartheld CS |
| Citation(s) |
22786898 |
| |
| Submission date |
Jun 18, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Amy L. Altick |
| E-mail(s) |
aaltick@medicine.nevada.edu
|
| Phone |
775-682-8841
|
| Fax |
775-784-6903
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| Organization name |
University of Nevada, Reno
|
| Department |
Physiology and Cell Biology
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| Lab |
von Bartheld
|
| Street address |
No. Virginia St., MS 352
|
| City |
Reno |
| State/province |
NV |
| ZIP/Postal code |
89557 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA168649 |
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