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Series GSE38754 Query DataSets for GSE38754
Status Public on Jun 16, 2012
Title Temporal changes of gene expression in mouse heart, kidney and lung during juvenile growth
Organism Mus musculus
Experiment type Expression profiling by array
Summary Temporal changes of gene expression from 1-wk- to 4-wk and 8-wk-old mouse in heart, kidney and lung. Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified >1600 genes that were regulated with age coordinately in kidney, lung, and heart of juvenile mice, including many genes that regulate proliferation. As examples, we focused on three growth-promoting genes, Igf2, Mest, and Peg3, that were markedly downregulated with age. We conclude that there exists an extensive genetic program occurring during postnatal life. Many of the involved genes are regulated coordinately in multiple organs, including many genes that regulate cell proliferation. At least some of these are themselves apparently regulated by growth, suggesting that, in the embryo, a gene expression pattern is established that allows for rapid somatic growth of multiple tissues but then, during postnatal life, this growth leads to negative-feedback changes in gene expression that in turn slow and eventually halt somatic growth, thus imposing a fundamental limit on adult body size.
Overall design To compare gene expression between fast-growing animals and more slowly growing animals, we extracted total mRNA from kidney and lung in 1-wk, 4-wk, and 8-wk-old mice (5 animals each).
Contributor(s) Lui JC, Nilsson O, Baron J
Citation(s) 19036884
Submission date Jun 15, 2012
Last update date Feb 11, 2019
Contact name Julian CK Lui
Phone 301-496-8049
Organization name NICHD, NIH
Lab Section on Growth and Development
Street address 10 Center Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (40)
GSM949115 1wk Kidney 1
GSM949116 1wk Kidney 2
GSM949117 1wk Kidney 3
BioProject PRJNA168592

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Supplementary file Size Download File type/resource
GSE38754_RAW.tar 256.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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