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| Status |
Public on Jun 21, 2012 |
| Title |
Expression data from dietary restricted budding yeast |
| Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
| Sample organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
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| Summary |
Dietary restriction (also known as caloric/calorie restriction; CR) extends the lifespan of species from all three eukaryotic kingdoms. The restriction of the diet interferes directly with the aging process by triggering a tightly controlled genetic program where specific sets of genes are either upregulated downreguled.
We used microarray-technology to detail the global program of gene expression underlying the anti-aging effect of dietary restriction and identified distinct classes of up- and down-regulated genes.
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| Overall design |
In order to apply dietary restriction in budding yeast we cultured cells on a reduced glucose medium (0.5% vs. 2.0%), which is known as moderate DR regimen. We then compared mRNA expression of yeast cells cultured under dietary restricted (0.5% glucose) and ad libitum (2.0% glucose) conditions.
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| Web link |
http://genomics.senescence.info/diet/
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| Contributor(s) |
Wuttke D, Tang F |
| Citation(s) |
22912585 |
| Submission date |
Jun 11, 2012 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Daniel Wuttke |
| E-mail(s) |
age@liv.ac.uk
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| Phone |
4915253306032
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| Organization name |
University of Liverpool
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| Department |
Department of Functional and Comparative Genomics
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| Lab |
Integrative Genomics of Ageing Group
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| Street address |
Crownstreet
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| City |
Liverpool |
| State/province |
Meyerside |
| ZIP/Postal code |
L69 7ZB |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA168299 |
