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Series GSE38303 Query DataSets for GSE38303
Status Public on Nov 22, 2012
Title Genomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small number of them, some 70 promoters. Among these, the large majority is bound by either RNA polymerase II or RNA polymerase III, as expected, but one gene hitherto considered an RNA polymerase III gene is also occupied by significant levels of RNA polymerase II, which synthesizes an RNA distinct from that synthesized by RNA polymerase III. Both RNA polymerase II and RNA polymerase III SNAPc- dependent promoters use a largely overlapping set of a few transcription activators, including GABP, a novel factor implicated in snRNA gene transcription.
Overall design SNAPc-dependent promoters in the human genome
Contributor(s) Faresse NJ, Canella D, Praz V, Michaud J, Romascano D, Hernandez N
Citation(s) 23166507
Submission date May 29, 2012
Last update date May 15, 2019
Contact name Viviane Praz
Organization name University of Lausanne
Department CIG
Lab Hernandez
Street address GĂ©nopode
City Lausanne
State/province VD
ZIP/Postal code 1015
Country Switzerland
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (11)
GSM938406 RPC4_ChIPSeq_1
GSM938407 RPC4_ChIPSeq_2
GSM938408 BRF2_ChIPSeq
BioProject PRJNA167635
SRA SRP013428

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Supplementary file Size Download File type/resource
GSE38303_RAW.tar 1.9 Mb (http)(custom) TAR (of BEDGRAPH)
GSE38303_RPC4_on_SNAPc_genes.bedGraph.gz 203.1 Kb (ftp)(http) BEDGRAPH
GSE38303_SNAP45_on_SNAPc_genes.bedGraph.gz 108.1 Kb (ftp)(http) BEDGRAPH
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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