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Series GSE37345 Query DataSets for GSE37345
Status Public on Jun 02, 2014
Title FoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [LNCaP, ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore, the role of FoxA1 itself in prostate cancer has not been carefully examined. Thus, it is important to understand the role of FoxA1 in prostate cancer and how it interacts with AR signaling. To address these questions, we generated LNCaP cells with stable FoxA1 knockdown. We performed AR/FoxA1 ChIP-seq and microarray analysis of these cells.
Overall design ChIP_Seq examination of AR and FoxA1 binding sites in LNCaP shCtrl and shFoxA1 cells
Contributor(s) Jin H, Yu J
Citation(s) 24875621
Submission date Apr 17, 2012
Last update date May 15, 2019
Contact name Hong-Jian Jin
Phone 3125033041
Organization name Northwestern University
Department Medicine
Street address 303 E Superior St
City Chicago
State/province IL - Illinois
ZIP/Postal code 60611
Country USA
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL15456 Illumina HiScanSQ (Homo sapiens)
Samples (9)
GSM916521 AR_ChIP-seq_shCtrl_R1881, biological replicate 1
GSM916522 AR_ChIP-seq_shFoxA1_R1881, biological replicate 1
GSM916523 FoxA1_ChIP-seq_shCtrl_R1881
This SubSeries is part of SuperSeries:
GSE55007 Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program
BioProject PRJNA159621
SRA SRP012266

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Supplementary file Size Download File type/resource
GSE37345_RAW.tar 250.0 Mb (http)(custom) TAR (of BEDGRAPH, TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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