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Series GSE37202 Query DataSets for GSE37202
Status Public on Sep 04, 2012
Title Evolutionary Significance of DNA Methylation in Human and Chimpanzee Brains
Organisms Pan troglodytes; Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated among the human tissues examined so far. Nevertheless, hundreds of genes exhibit dramatically reduced levels of promoter DNA methylation in the human brain relative to the chimpanzee brain. Many of these genes are associated with neurological disorders, psychological disorders, and cancers, and are enriched for functions related to cellular metabolic processes and protein binding. Moreover, the majority of these genes exhibit higher expression in the human brain compared to the chimpanzee brain.
 
Overall design Profiling DNA methylation map in prefrontal cortex regions of postmortem brains of three humans and three chimpanzees
 
Contributor(s) Jia Z, Soojin Y
Citation(s) 22922032
Submission date Apr 11, 2012
Last update date Dec 03, 2018
Contact name Jia Zeng
E-mail jzeng6@mail.gatech.edu
Phone 3029815141
Organization name Georgia Institute of Technology
Department School of Biology
Street address Georgia Institute of Technology
City Atlanta
State/province GA
ZIP/Postal code 30332
Country USA
 
Platforms (3)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL15433 Illumina HiSeq 1000 (Homo sapiens)
GPL15434 Illumina HiSeq 1000 (Pan troglodytes)
Samples (6)
GSM913595 Hs1570
GSM913596 Hs1832
GSM913597 Hs813
Relations
BioProject PRJNA158561
SRA SRP012161

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37202_RAW.tar 21.7 Gb (http)(custom) TAR (of GFF)
Raw data are available in SRA
Processed data provided as supplementary file

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