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Series GSE37055 Query DataSets for GSE37055
Status Public on Jul 20, 2012
Title Cell-type specific postnatal developmental expression data from mouse cerebellar Purkinje and Stellate/Basket cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary The assembly of neural circuits involves multiple sequential steps such as the specification of cell types, their migration to proper brain locations, morphological and physiological differentiation, and the formation and maturation of synaptic connections. This intricate and often prolonged process is guided by elaborate genetic mechanisms that regulate each developmental event. Evidence from numerous systems suggests that each cell type, once specified, is endowed with a genetic program that directs its subsequent development. This cell intrinsic program unfolds in respond to, and is regulated by, extrinsic signals, including cell-cell and synaptic interactions. To a large extent, the execution of this genetic program is achieved by the expression of specific sets of genes that support distinct developmental processes. Therefore, a comprehensive analysis of the developmental progression of gene expression in synaptic partners of neurons may provide a basis for exploring the genetic mechanisms regulating circuit assembly.
Here we examined the developmental gene expression profiles in well defined cell types in a stereotyped microcircuit of the cerebellar cortex.
Overall design Manually sorted pure populations of Purkinje cells and Stellate/Basket cells, 3 biological replicates, from Gad67-GFP bac-transgenic (G42) mice were profiled during postnatal developmental stages P3, P7, P14, P21, P28, P35 and P56 using Affymetrix MOE430.2 expression array
Contributor(s) Paul A, Huang ZJ
Citation(s) 22754500
Submission date Apr 04, 2012
Last update date Feb 11, 2019
Contact name Anirban Paul
Organization name Cold Spring Harbor Laboratory
Street address 1 Bungtown Road
City Cold Spring Harbor
State/province NY
ZIP/Postal code 11724
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (42)
GSM909413 Purkinj cells at P03, biological rep1
GSM909414 Purkinj cells at P03, biological rep2
GSM909415 Purkinj cells at P03, biological rep3
BioProject PRJNA157839

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Supplementary file Size Download File type/resource
GSE37055_RAW.tar 159.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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