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| Status |
Public on Mar 30, 2012 |
| Title |
Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. A significant correlation between higher disease activity and lower serum 25-hydroxyvitamin D levels was also shown.
This preliminary study suggests the beneficial role of vitamin D in SLE patients and needs to be confirmed in randomized controlled trials.
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| Overall design |
In this prospective study, we evaluated the safety and the immunological effects of vitamin D supplementation in 20 SLE patients with hypovitaminosis D using transcriptomic study at M0 and M2.
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| Contributor(s) |
Terrier B, Derian N, Schoindre Y, Chaara W, Geri G, Zahr N, Mariampillai K, Rosenzwajg M, Carpentier W, Musset L, Piette J, Six A, Klatzmann D, Saadoun D, Cacoub P, Costedoat-Chalumeau N |
| Citation(s) |
23075451 |
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| Submission date |
Mar 29, 2012 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Nicolas DERIAN |
| E-mail(s) |
nicolas.derian@upmc.fr
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| Phone |
0033 142 176 515
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| Organization name |
UMR 7211
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| Department |
Biotherapy
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| Street address |
15 Avenue Pitié
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| City |
PARIS |
| ZIP/Postal code |
75012 |
| Country |
France |
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| Platforms (2) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA157315 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36941_GPL13475_non-normalized.txt.gz |
3.7 Mb |
(ftp)(http) |
TXT |
| GSE36941_GPL6947_non-normalized.txt.gz |
4.0 Mb |
(ftp)(http) |
TXT |
| GSE36941_RAW.tar |
32.4 Mb |
(http)(custom) |
TAR |
| Processed data included within Sample table |
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