NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE36820 Query DataSets for GSE36820
Status Public on Mar 27, 2012
Title Expression data from ACC xenografts and normal salivary glands
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm (incidence of 0.35 per 100,000) that occurs in different body sites. It most often arises in salivary glands and other secretory glands in the head and neck region. To find the gene expression signatures of ACC, we performed microarray experiments to compare ACC xenograft tumor models and normal tissue samples. We used microarrays to detail the global program of gene expression underlying adenoid cystic carcinoma and identified distinct classes of up- and down-regulated genes compared to non-neoplastic salivary tissue.
 
Overall design Viable tumor tissue samples from human patients were used to establish xenograft tumor models in nude/nude immunodeficient mice. Tissue from these tumor models were compared to tissue samples of normal human salivary glands. Tissue samples were frozen, examined by cryostat histologic sectioning and macrodissected to obtain samples that represented at least 70% epithelial cells.
 
Contributor(s) Moskaluk CA, Papin JA, Chowbina SR, Prorock A, Bao Y
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Mar 26, 2012
Last update date Jan 08, 2019
Contact name Sudhir R Chowbina
Organization name SAIC-Frederick
Department Advanced Biomedical Computing Center
Street address Frederick
City Frederick
State/province MD
ZIP/Postal code 21703
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (14)
GSM902385 Normal Sample 1
GSM902386 Normal Sample 2
GSM902387 Normal Sample 3
Relations
BioProject PRJNA156925

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36820_RAW.tar 114.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap